Endocrine Abstracts

Objective: This study aimed to assess the early results of the effect of antidiabetic drugs on serum 25-hydroxyvitamin D (25(OH)D) level in patients with type 2 diabetes mellitus (T2DM).Methods: Thirty-five patients with T2DM having vitamin D deficiency (<20 ng/ml) or insufficiency (<30 ng/ml) were included. They were divided into 5 groups according to the drug therapy (metformin alone (n=9), metformin in combination with insulin (n<...

Background: Ukraine does not yet have a national program for control of iodine deficiency and there are no recent data on the severity of the iodine deficiency disorders (IDD) in the country.Objective: The aim of the present study was to assess current IDD status in eastern Ukraine.Design: We conducted school-based 30-cluster survey in children 6-11-year-old in urban and rural areas. We measured urinary iodine concentration (UI) an...

IntroductionThe aim of this study, which was conducted for the first time in Ukraine, was to analyze a glycemic control in patients with different types of diabetes mellitus (DM), including neonatal (ND) and maturity onset diabetes of the young (MODY) and changing their treatment after the results of genetic testing.Materials and methodsThe Ukrainian Pediatric Diabetes Register was established in 2002 and inc...

Background: Low bone mineral density (BMD) and osteoporosis are the frequent consequences of Turner Syndrome (TS).Objective and hypotheses: We examined the BMD in TS girls with different age and karyotype.Methods: Measurements of BMD (g/cm2), Z-score (S.D.) were conducted in 26 girls using X-ray absorptiometry (DEXA) at the lumbar spine L2–L4 depending on the child’s age.<p class="ab...

Background: One of the markers of bone metabolism is osteocalcin (OC) and Its elevated level indicates osteoporosis.Objective and hypotheses: We investigated the OC level in 14 girls with TS (45,X (n=8), 45,X/46,XX (n=3), structural abnormalities of chromosome X (n=3): seven patients at 4–11 year and 7 – at 12–18 year.Method: DEXA (Z-score, S.D.), serum levels of OC,...

Objective: Growth hormone (GH) replacement therapy currently requires daily injections. This may cause poor compliance, inconvenience and distress for patients. CTP-modified hGH (MOD-4023) has been developed for once-weekly administration in growth hormone deficient (GHD) adults and children. The 18 and 24 month efficacy of once-weekly subcutaneous (SC) administration of MOD-4023 was evaluated in a Phase 2 study in children with GH deficiency.Design and ...

Objective: Growth hormone (GH) replacement therapy currently requires daily injections. This may cause poor compliance, inconvenience and distress for patients. CTP-modified human GH (MOD-4023) has been developed for once-weekly administration in growth hormone-deficient (GHD) adults and children. In the present Phase 2 study, the safety and tolerability of once-weekly subcutaneous (SC) administration of MOD-4023 were evaluated in GHD children.Design and...